MF.03 The Gilles de la Tourette Syndrome behavioural spectrum: a factor analysis of 639 patients
Identifieur interne : 000077 ( Main/Exploration ); précédent : 000076; suivant : 000078MF.03 The Gilles de la Tourette Syndrome behavioural spectrum: a factor analysis of 639 patients
Auteurs : A E Cavanna ; H D Critchley ; M. Orth ; J S Stern ; M-B Young ; M M RobertsonSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2011-08.
Abstract
Aims Recent studies using quantitative methods, such as principal-component factor analysis, hierarchical cluster analysis and latent class analysis, have suggested that Gilles de la Tourette syndrome (GTS) should no longer be considered a unitary condition as in current classification systems. We set out to identify quantitative components of GTS symptomatology using a large, well characterised cohort of singleton individuals with GTS, in order to inform future genetic studies with more homogeneous phenotypes. Methods Principal-component factor analysis with oblique rotation was used to analyse symptom data from a sample of 639 patients recruited at two tertiary referral centres using identical schedules during the period 1980–2008. Results Three Factors were identified: (1) complex motor tics and echo-paliphenomena; (2) attention-deficit and hyperactivity symptoms plus aggressive behaviours; (3) complex vocal tics and coprophenomena. Obsessive compulsive behaviours loaded significantly on the first two Factors. The three Factors accounted for 48.5% of the total symptomatic variance. Conclusions GTS is a phenotypically heterogeneous condition encompassing tics, tic-related symptoms and associated behavioural problems. Our results, coupled with previous findings, identified a clinical continuum of complex involuntary movements, hyperactivity/impulsivity symptoms, and semantically relevant utterances and gestures. A better characterisation of the GTS phenotypes will help to identify susceptibility genes.
Url:
DOI: 10.1136/jnnp-2011-300504.14
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>MF.03 The Gilles de la Tourette Syndrome behavioural spectrum: a factor analysis of 639 patients</title><author><name sortKey="Cavanna, A E" sort="Cavanna, A E" uniqKey="Cavanna A" first="A E" last="Cavanna">A E Cavanna</name></author><author><name sortKey="Critchley, H D" sort="Critchley, H D" uniqKey="Critchley H" first="H D" last="Critchley">H D Critchley</name></author><author><name sortKey="Orth, M" sort="Orth, M" uniqKey="Orth M" first="M" last="Orth">M. Orth</name></author><author><name sortKey="Stern, J S" sort="Stern, J S" uniqKey="Stern J" first="J S" last="Stern">J S Stern</name></author><author><name sortKey="Young, M B" sort="Young, M B" uniqKey="Young M" first="M-B" last="Young">M-B Young</name></author><author><name sortKey="Robertson, M M" sort="Robertson, M M" uniqKey="Robertson M" first="M M" last="Robertson">M M Robertson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AA97E8A0A1E55B4E52A67F51E17C8471F521F9AC</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1136/jnnp-2011-300504.14</idno><idno type="url">https://api.istex.fr/document/AA97E8A0A1E55B4E52A67F51E17C8471F521F9AC/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">003013</idno><idno type="wicri:Area/Main/Curation">002C22</idno><idno type="wicri:Area/Main/Exploration">000077</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">MF.03 The Gilles de la Tourette Syndrome behavioural spectrum: a factor analysis of 639 patients</title><author><name sortKey="Cavanna, A E" sort="Cavanna, A E" uniqKey="Cavanna A" first="A E" last="Cavanna">A E Cavanna</name></author><author><name sortKey="Critchley, H D" sort="Critchley, H D" uniqKey="Critchley H" first="H D" last="Critchley">H D Critchley</name></author><author><name sortKey="Orth, M" sort="Orth, M" uniqKey="Orth M" first="M" last="Orth">M. Orth</name></author><author><name sortKey="Stern, J S" sort="Stern, J S" uniqKey="Stern J" first="J S" last="Stern">J S Stern</name></author><author><name sortKey="Young, M B" sort="Young, M B" uniqKey="Young M" first="M-B" last="Young">M-B Young</name></author><author><name sortKey="Robertson, M M" sort="Robertson, M M" uniqKey="Robertson M" first="M M" last="Robertson">M M Robertson</name></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2011-08">2011-08</date><biblScope unit="volume">82</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="e2">e2</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">AA97E8A0A1E55B4E52A67F51E17C8471F521F9AC</idno><idno type="DOI">10.1136/jnnp-2011-300504.14</idno><idno type="href">jnnp-82-e2-6.pdf</idno><idno type="ArticleID">jnnp-2011-300504.14</idno><idno type="local">jnnp;82/8/e2-n</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Aims Recent studies using quantitative methods, such as principal-component factor analysis, hierarchical cluster analysis and latent class analysis, have suggested that Gilles de la Tourette syndrome (GTS) should no longer be considered a unitary condition as in current classification systems. We set out to identify quantitative components of GTS symptomatology using a large, well characterised cohort of singleton individuals with GTS, in order to inform future genetic studies with more homogeneous phenotypes. Methods Principal-component factor analysis with oblique rotation was used to analyse symptom data from a sample of 639 patients recruited at two tertiary referral centres using identical schedules during the period 1980–2008. Results Three Factors were identified: (1) complex motor tics and echo-paliphenomena; (2) attention-deficit and hyperactivity symptoms plus aggressive behaviours; (3) complex vocal tics and coprophenomena. Obsessive compulsive behaviours loaded significantly on the first two Factors. The three Factors accounted for 48.5% of the total symptomatic variance. Conclusions GTS is a phenotypically heterogeneous condition encompassing tics, tic-related symptoms and associated behavioural problems. Our results, coupled with previous findings, identified a clinical continuum of complex involuntary movements, hyperactivity/impulsivity symptoms, and semantically relevant utterances and gestures. A better characterisation of the GTS phenotypes will help to identify susceptibility genes.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cavanna, A E" sort="Cavanna, A E" uniqKey="Cavanna A" first="A E" last="Cavanna">A E Cavanna</name><name sortKey="Critchley, H D" sort="Critchley, H D" uniqKey="Critchley H" first="H D" last="Critchley">H D Critchley</name><name sortKey="Orth, M" sort="Orth, M" uniqKey="Orth M" first="M" last="Orth">M. Orth</name><name sortKey="Robertson, M M" sort="Robertson, M M" uniqKey="Robertson M" first="M M" last="Robertson">M M Robertson</name><name sortKey="Stern, J S" sort="Stern, J S" uniqKey="Stern J" first="J S" last="Stern">J S Stern</name><name sortKey="Young, M B" sort="Young, M B" uniqKey="Young M" first="M-B" last="Young">M-B Young</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000077 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000077 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:AA97E8A0A1E55B4E52A67F51E17C8471F521F9AC
|texte= MF.03 The Gilles de la Tourette Syndrome behavioural spectrum: a factor analysis of 639 patients
}}
| This area was generated with Dilib version V0.6.23. |  |